Police and ambulance crews were called to reports of a disturbance near the Co-op in Somercotes Hill at about 1.40am.
Two men were found injured at the scene and taken to hospital.
One of the men, who was 22, sadly died in hospital.
The other man was discharged yesterday, and his injuries are not believed to be serious.
Four men were arrested in connection with the incident and remain in custody.
An investigation into the circumstances is ongoing and people living in Somercotes will see an increased police presence throughout the day.
Anyone with concerns is encouraged to speak to officers but we would like to reassure people that we believe this to be an isolated incident.
Witnesses or anyone with information about the assault can contact us using one of the below methods, quoting reference 21*686560:
- Facebook– send us a private message to /DerbyshireConstabulary
- Twitter– direct message our contact centre on @DerPolContact
- Website– complete the online contact form derbyshire.police.uk/Contact-Us.
- Phone – call us on 101.
You can also call Crimestoppers anonymously on 0800 555 111.